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曹小娟

发布时间:2024-01-08来源:


职称 教授

电话 13006151853

邮箱caoxiaojuan@mail.hzau.edu.cn

政治面貌:中共党员

研究方向 水产动物遗传育种与健康养殖研究


教育经历

20069月至20116月在海燕策略官网海燕策略官网学习,获博士学位

200810-20105,美国俄亥俄州立大学,联合培养博士

20029月至20066月在海燕策略官网海燕策略官网学习,获学士学位

主要职历

202312-至今海燕策略官网,教授

201312-202312月,海燕策略官网,副教授

20117-201312月,华中农业大海燕策略官网,讲师

科研成果

主持和参与的科研项目:

1.国家自然科学基金青年基金项目,31201719、泥鳅肠气呼吸功能的发生与发育及其分子调控机制、2013/01-2015/12、主持

2.中克政府间合作项目,6-4、中国和克罗地亚鳅属鱼类形态与分子进化比较研究、2014/01-2015/12、主持

3.中央高校基本科研业务费专项资金资助项目,2662015PY033、泥鳅杂种未减数配子形成的细胞和分子机制、2015/01-2017/12、主持

4.武汉市青年科技晨光计划,2016070204010141、优质泥鳅种苗繁育技术开发与示范 2016/08-2018/08, 主持

5.其他市级项目,螺蛳养殖产业技术研发与技术培训服务、2018/11-2022/11、参与

6.国家重点研发计划蓝色粮仓科技创新重点专项水产养殖生物性别和发育的分子基础与调控机制项目子课题主持,2018/12-2022/12

7.重点实验室开放课题,泥鳅 chop基因敲除系的建立及其功能研究、2019/01-2020/12、主持

8.农业农村部项目,长江长薄鳅野生资源调查及其种群遗传多样性研究、2019/01-2019/12、主持

9.农业农村部项目,中华沙鳅种质资源保存与增殖、2020/03-2020/12、主持

10.教育部项目,长江特有珍稀鳅科鱼类种质资源挖掘与创新利用、2020/5-2022/4、主持

11.横向科研项目,水产动物遗传育种、2021/09-2022/08、主持

12.横向科研项目,泥鳅种质保护与多倍体泥鳅繁育研究、2022/01-2023/12、主持

13.国家自然科学基金(面上项目),Cdk1缺失引发泥鳅多倍体产生的机理研究、2022/01-2025/12、主持

14.国家重点研发计划子课题,螺蛳大规格高出肉率新品种(系)培育、2022/09-2026/12、主持

15.横向科研项目,脂类营养对长薄鳅卵巢发育调控机制研究、2022/10-2025/10、主持

青年科学家项目(省重点研发),基因突变体介导的鱼类人工多倍体创制技术研发、2023-2025、主持

发表的科研论文:

1.Zhang YB, Lv MQ, Jiang HJ, Li H, Li RY, Yang C, Huang YW, Zhou H, Mei YH, Gao J*, Cao XJ*. Mitotic defects lead to unreduced sperm formation in cdk1-/- mutants. Int J Biol Macromol, 2023, 242:125171. doi: 10.1016/j.ijbiomac.2023.125171.

2.Lv MQ, Zhang YB, Yang LJ, Cao XJ*. Depletion of chop suppresses procedural apoptosis and enhances innate immunity in loach Misgurnus anguillicaudatus under ammonia nitrogen stress. J Anim Sci, 2023, 101:skad114. doi: 10.1093/jas/skad114.

3.Benhe Ma, Wu Jin, Huiyun Fu, Bing Sun, Su Yang, Xueyan Ma, Haibo Wen, Xiaoping Wu, Haihua Wang*, Xiaojuan Cao*. A High-Quality Chromosome-Level Genome Assembly of a Snail Cipangopaludina cathayensis (Gastropoda: Viviparidae). Genes, 2023, 14(7): 1365; https://doi.org/10.3390/genes14071365

4.Ziyu Zhou#, Gu Shan#, Xin Li, Wenxuan Guo, Kexin Ma, Yueyao Yang, Yifan Li, Yunbang Zhang, He Zhou*, Xiaojuan Cao*. De Novo Transcriptome Analysis of the Early Hybrid Triploid Loach (Misgurnus anguillicaudatus) Provides Novel Insights into Fertility Mechanism. Fishes, 2023, 8(2): 70; https://doi.org/10.3390/fishes8020070

5.Sun B, Huang Y, Castro L, Yang S, Huang S, Jin W, Zhou H, Ijiri S, Luo Y, Gao J*, Cao X*. The chromosome-level genome and key genes associated with mud-dwelling behavior and adaptations of hypoxia and noxious environments in loach (Misgurnus anguillicaudatus). BMC Biology, 2023, 21: 18.  DOI : 10.1186/s12915-023-01517-1.

6.Li, HuiKang, MinxinSun, ShouxiangGao, JianJia, Zhiying*Cao, Xiaojuan*. Cloning and expressions of chop in loach (Misgurnus anguillicaudatus) and its response to hydrogen peroxide (H2O2) stress. Fish Physiology and Biochemistry, 2022, 48:659–668

7.Sun B, Gao J, Yang LJ, Huang SQ, Cao XJ*. Depletion of LOXL2 improves respiratory capacity: From air-breathing fish to mammal under hypoxia. International Journal of Biological Macromolecules, 2022, 209: 563-575

8.Jin W#, Cao XJ#, Ma XY, Lv GH, Xu GC, Xu P, Sun B, Xu DP*, Wen HB*. Chromosome-level genome assembly of the freshwater snail Bellamya purificata (Caenogastropoda). Zoological Research, 2022, 43(4): 683-686.

9.Huang SQ#, Sun B#, Huang LF, Yang LJ, Liu CS, Zhu JL, Gao J*, Cao XJ*. Comparative Transcriptomic Analysis of Regenerated Skins Provides Insights into Cutaneous Air-Breathing Formation in Fish. Biology-basel, 2021, 10(12): 1294.

10.Yuwei Huang, Yunbang Zhang, Jian Gao, Xiaojuan Cao*. Expression profiles of cdca9 related to ovarian development in loach (Misgurnus anguillicaudatus). Journal of Fish Biology, 2022, 100(5): 1319-1322

11.Huang SQ, Yang LJ, Zhang L, Sun B, Gao J, Chen ZJ, Zhong L*, Cao XJ*. Endogenic upregulations of HIF/VEGF signaling pathway genes promote air breathing organ angiogenesis in bimodal respiration fish. Functional & Integrative Genomics, 2022, 22:65–76

12.Sun B#, Huang SQ#, Huang LF, Yang LJ, Gao J*, Cao XJ*. Fibronectin 1B gene plays an important role in loach barbel air-breathing. International Journal of Molecular Sciences, 2021, 22(21): 11928.

13.Zhong L, Wang WM, Cao XJ*. Species-Specific Duplication and Adaptive Evolution of a Candidate Sex Pheromone Receptor Gene in Weather Loach. Genes, 2021, 12(12): 1845.

14.Zhang YB, Gao J, Zhang YH, Zou YC*, Cao XJ*. Transcriptome Sequencing of the Endangered Species Elongate Loach (Leptobotia elongata) From the Yangtze River: De novo Transcriptome Assembly, Annotation, Identification and Validation of EST-SSR Markers. Frontiers in Marine Science, 2021, 8: 616727.

15.Huang SQ, Jiang HJ, Zhang L, Gu QH, Wang WM, Wen YH, Luo FG, Jin W*, Cao XJ*. Integrated proteomic and transcriptomic analysis reveals that polymorphic shell colors vary with melanin synthesis in Bellamya purificata snail. Journal of Proteomics, 2021, 230: 103950.

16.Huang S, Zhang L, Cao X*, Wang WM. Fertility and gamete ploidy of allopentaploid offspring of tetraploid dojo loach Misgurnus anguillicaudatus females and large-scale loach Paramisgurnus dabryanus males. Fisheries Science, 2020, 86(5): 741-748.

17.Hussein MNA, Cao XJ*, Elokil AA, Huang SQ. Characterization of stem and proliferating cells on the retina and lens of loach Misgurnus anguillicaudatus. Journal of Fish Biology, 2020, 96(1): 102-110.

18.Xiuwen Xu#, Xiaojuan Cao#,*, Jian Gao. Production of a mutant of large-scale loach Paramisgurnus dabryanus with skin pigmentation loss by genome editing with CRISPR/Cas9 system. Transgenic Research, 2019, 28: 341-356.

19.Jianxun Li, Chuang Yang, Longfei Huang, Kewei Zeng, Xiaojuan Cao*, Jian Gao*. Inefficient ATP synthesis by inhibiting mitochondrial respiration causes lipids to decrease in MSTN-lacking muscles of loach Misgurnus anguillicaudatus. Functional & Integrative Genomics, 2019, 19: 889-900.

20.He Zhou, Qi-Zheng Xu, Rui Zhang, Zi-Xin Zhuang, Yin-Qiang Ma, Wei Wang, Tian-Yu Ma, Yi Sui, Yang Liu, Xiao-Juan Cao*. Gonadal transcriptome analysis of hybrid triploid loaches (Misgurnus anguillicaudatus) and their diploid and tetraploid parents. Plos One, 2018, 13(5): e0198179.

21.Huang SQ, Cao XJ*, Wang WM, Nasr M. Fertility and ploidy of gametes of allodiploid and allotriploid loach produced by diploid Misgurnus anguillicaudatus females and Paramisgurnus dabryanus males. Fish physiology & biochemistry, 2018, 44: 13-20.


授权和申请专利:

1. 曹小娟,王卫民,白晓慧,田先畅. 一种二倍体泥鳅微卫星家系鉴定方法及其应用. 专利号:201410139536.1

4. 曹小娟,王卫民,黄松钱,高坚,田先畅. 一种通过种间杂交获得高比例雄性泥鳅的方法. 专利号:201410111329.5

5. 曹小娟,王卫民,黄松钱,田先畅,高坚. 一种通过种间杂交获得高比例雌性泥鳅的方法. 专利号:201410110587.1

6. 高坚,曹小娟,王卫民,陈钢铭,彭鑫. 一种泥鳅大规格苗种培育池和培育方法. 专利号:201410110588.6

7. 高坚,曹小娟. 一种泥鳅仔稚鱼饲料及制备方法. 专利号:201410312904.8

8. 黄松钱,曹小娟,田先畅,王卫民. 一种通过抑制受精卵极体释放获得异源多倍体泥鳅的方法. 专利号:201410581532.9

9. 高坚,徐秀文,曹小娟,彭鑫,王卫民. 一种刺鳅人工繁殖方法. 专利号:201510812385.6

10. 曹小娟,彭鑫,徐秀文,王卫民,田先畅,徐佳. 一种鉴别泥鳅与大鳞副泥鳅纯种和杂种的方法. 专利号:201510993152.0

11. 曹小娟,徐秀文,高坚,彭鑫. 一种泥鳅良种选育中家系个体荧光标记方法. 专利号:201610287369.4

12. 曹小娟,徐秀文,高坚. 一种能够稳定遗传的白化大鳞副泥鳅育种方法. 专利号:201710014992.7

13. 曹小娟,张运邦,高坚. 一种人工诱导多倍体泥鳅的方法. 专利号:ZL 202111371545.X

14. 曹小娟,张运邦,高坚,杨闯. 泥鳅CDK1基因及其在不育多倍体泥鳅分子育种中的应用. 专利号:ZL 2021 1 1369875.5

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