职称 教授

学位 博士

政治面貌 中共党员

电话 13277085693

邮箱 huanlingok@mail.hzau.edu.cn

 研究方向 分子遗传与鱼类育种

 

 教育经历 

2001/09-2006/06，海燕策略官网动物科技学院，动物遗传育种与繁殖，博士

1997/09-2001/06，河北农业大学动物科技学院，畜牧，学士

 主要职历 

2019/12 - 至今，海燕策略官网，海燕策略官网，教授

2012/05 - 2013/06，美国哈佛大学，医学院，访问学者

2011/01 - 至今，海燕策略官网，海燕策略官网，博士生导师

2009/01 - 2019/11，海燕策略官网，海燕策略官网，副教授

2006/07 - 2008/12，海燕策略官网，海燕策略官网，讲师

 科研成果 

一、科研项目

1. 国家自然科学基金面上项目，低氧胁迫下团头鲂miR-462-731介导的Akt-FoxO通路在调控线粒体功能中的作用机制，2019-2022

2. 广西科技重大专项，广西主导（特色）水产种质资源的收集、评价与鉴定，2017-2021

3. 广西水产遗传育种与健康养殖重点实验室开放基金，miRNA在凡纳滨对虾氨氮适应中的功能研究，2017-2018

4. 中央高校专项基金，2662015PY205，鱼类特异的miR-462-731簇在低氧调节中的作用机制，2016-2017

5. 留学回国人员科研启动基金，miR-462/731簇在HIF-1α介导的低氧调节中的作用及功能，2015-2016

6. 中央高校专项基金，2013PY067，团头鲂耐低氧性状优良品系选育研究，2013-2015

7. 教育部新世纪优秀人才计划项目，2010年，水产

8. 国家自然科学基金青年项目，RNA干扰沉默HIF-1在几种鱼类低氧调节中的分子机理研究，2010-2012

9. 国际科学基金（IFS），Population structure and genetic diversity of Chinese sucker in the Yangzte river basin，2009-2011

 

二、科研论文

1. Huang CX, Huang Y, Duan XK, Zhang M, Tu JP, Liu JX, Liu H, Chen TS, Wang WM, Wang HL*. Zebrafish miR-462-731 regulates hematopoietic specification and pu.1-dependent primitive myelopoiesis. Cell Death Differ. 2018 Nov 20. doi: 10.1038/s41418-018-0234-0    (IF:8.0) 

2. Chen N, Huang CX, Huang CH, He Y, Chen TS, Zhu DM, Liu H, Wang WM, Wang HL*. The molecular characterization, expression pattern and alternative initiation of Hif prolyl hydroxylase Phd1. Gene, 2018, 678: 219-225  (IF:2.415) 

3. He Y, Huang CX, Chen N, Wu M, Huang Y, Liu H, Tang R, Wang WM, Wang HL*.The zebrafish miR-125c is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations and embryogenesis.Oncotarget. 2017, 8 (43) : 73846-73859  (IF:5.165) 

4. Chen N, Wu M, Wang HJ, Liu H, Wang WM, Wang HL*. Effects of Acute Hypoxia and Reoxygenation on Physiological and Immune Responses and Redox Balance of Wuchang Bream (Megalobrama amblycephala Yih, 1955), Front. Physiol., 2017, 8:375  (IF:4.134)

5. Chen BX, Yi SK, Wang WF, He Y, Huang Y, Gao ZX, Liu H, Wang WM, Wang HL*.Transcriptome comparison reveals insights into muscle response to hypoxia in blunt snout bream (Megalobrama amblycephala). Gene. 2017, 624:6-13.  (IF:2.415)

6. Huang CX, Chen N, Wu XJ, He Y, Huang CH, Liu H, Wang WM, Wang HL*. Zebrafish let-7b acts downstream of hypoxia-inducible factor-1α to assist in hypoxia-mediated cell proliferation and cell cycle regulation. Life Sciences, 2017, 171:21-29  (IF:2.936)

7. Huang CH, Chen N, Huang CX, Zhang B, Wu M, He L, Liu H, Tang R, Wang WM, Wang HL*, Involvement of miR-462/731 cluster in hypoxia response in Megalobrama amblycephala. Fish Physiol Biochem, 2017, 43(3):863-873  (IF:1.647)

8. Wu M, Chen N, Huang CX, He Y, Zhao YZ, Chen XH, Chen XL*, and Wang HL*. Effect of Low Temperature on Globin Expression, Respiratory Metabolic Enzyme Activities, and Gill Structure of Litopenaeus vannamei. Biochemistry (Moscow), 2017, 82(7): 844-851  (IF:1.537)

9. Huang CX, Chen N, Wu XJ, Huang CH, He Y, Tang R, Wang WM, Wang HL*. The zebrafish miR-462/miR-731 cluster is induced under hypoxic stress via hypoxia-inducible factor 1α and functions in cellular adaptations. FASEB J. 2015, 29(12): 4901-13 (IF:5.043)

10. Chen N, Wang WM, Wang HL*. An efficient full-length cDNA amplification strategy based on bioinformatics technology and multiplexed PCR methods. Sci Rep, 2016，5:19420.  (IF:5.578)

11. Zhang B, Chen N, Huang CH, Huang CX, Chen BX, Liu H, Wang WM, Wang HL*, Molecular response and association analysis of Megalobrama amblycephala fih-1 with hypoxia, Mol Genet Genomics,  2016, 291(4): 1615-24 (IF: 2.728)

12. Chen N, Huang CH, Liu H, Chen BX, Wang WM, Wang HL*. Alternative splicing transcription of Megalobrama amblycephala HIF prolyl hydroxylase PHD3 and up-regulation of PHD3 by HIF-1α. Biochem Biophys Res Commun, 2016, 469(3): 737-42.  (IF:2.297)

13. Wang HJ, Huang CX, Chen N, Zhu KC, Chen BX, Wang WM, Wang HL*. Molecular characterization and mRNA expression of HIF-prolyl hydroxylase-2 (phd2) in hypoxia-sensing pathways from Megalobrama amblycephala. Comp Biochem Physiol B Biochem Mol Biol. 2015, 186:28-35  (IF:1.551)

14. Zhu KC, Yu DH, Zhao JK, Wang WM, Wang HL*. Morphological analysis and muscle-associated gene expression during different muscle growth phases of Megalobrama amblycephala. Genet Mol Res. 2015, 14(3):11639-51.  (IF:0.775)

15. Xu MX, Huang CX, Chen N, Wu XJ, Zhu KC,Wang WM, Wang HL*, Sequence analysis and expression regulation of rbp4 by 9-cis-RA in Megalobrama amblycephala, Fish Physiol Biochem. 2015, 41(2):437-47  (IF:1.622)

16. Chen N,  Wan XL,  Huang CX,  Wang WM, Liu H, Wang HL*. Study on the immune response to recombinant Hsp70 protein from Megalobrama amblycephala, Immunobiology, 2014, 219, 850–858  (IF:3.044)

17. Zhang J, Wei XL, Chen LP, Chen N, Xu MX, Huang C, Wang WM, Wang HL*. Characterization of a novel CC chemokine CCL4 in immune response induced by nitrite and its expression differences among three populations of Megalobrama amblycephala. Fish & shellfish immunology. 2014, 38(1), 88-95  (IF:2.674)

18. Zhu KC, Wang HL*, Wang HJ, Yasmeen Gul, Yang M, Zeng C, Wang WM, Characterization of muscle morphology and satellite cells, and expression of muscle-related genes in skeletal muscle of juvenile and adult Megalobrama amblycephala, Micron, 2014, 64, 66–75   (IF:1.988)

19. Zhu KC, Chen LP, Zhao JK, Wang HJ, Wang WM, Li Z, Wang HL*.Molecular characterization and expression patterns of myogenin in compensatory growth of Megalobrama amblycephala.Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2014,170, 10–17  (IF:1.551)

20. Huang CX, Wei XL, Chen N, Zhang J, Chen LP, Wang WM, Li JY, Wang HL*.Growth differentiation factor 9 of Megalobrama amblycephala: molecular characterization and expression analysis during the development of early embryos and growing ovaries. Fish Physiol Biochem. 2014, 40(1):193-203  (IF:1.622)

21. Zhang J, Wei XL, Chen LP, Chen N, Li YH, Wang WM, Wang HL*.Sequence analysis and expression differentiation of chemokine receptor CXCR4b among three populations of Megalobrama amblycephala, Dev Comp Immunol, 2013, 40(2):195-201  (IF:3.705)

22. Chen LP, Zhang J, Wei XL, Chen N, Huang CX, Xu MX, Wang WM, Wang HL*.Megalobrama amblycephala cardiac troponin T variants: Molecular cloning, expression and response to nitrite. Gene, 2013, 527(2):558-64  (IF:2.082)

23. Liu SS, Zhu KC, Chen N, Wang WM, Wang HL*.Identification of HIF-1α promoter and expression regulation of HIF-1α gene by LPS and hypoxia in zebrafish,Fish Physiol Biochem, 2013, 39(5):1153-63 (IF:1.676)

24. Chen N, Chen LP, Zhang J, Chen C, Wei XL, Gul Y, Wang WM, Wang HL*,Molecular cloning, characterization and expression analysis of three hypoxia inducible factor alpha subunits, HIF-1α, HIF-2α and HIF-3α of the endangered hypoxia-sensitive freshwater species, Myxocyprinus asiaticus, Gene, 2012,498, 81-90  (IF:2.341)

25. Zhu KC, Wang HL*, Gul Y, Zhao YH, Wang WM, Liu SS, Expression characterization and the promoter activity analysis of zebrafish hdac4,Fish Physiol Biochem, 2012, 38(2), 585-93 (IF:1.545)

26. Chen N, Wang WM, Wang HL*.Isolation of polymorphic microsatellite loci from an endangered freshwater species Chinese sucker, Myxocyprinus asiaticus,Conserv Genet Resour, 2010, 2, 73–75  (IF:1.255)

27. Zhu KC, Wang WM, Yan BL, Gul Y, Wang HL*.Development of polymorphic microsatellite markers for the swimming crab, Portunus trituberculatus (Miers, 1876), Conserv Genet Resour, 2010, 2, 117–119  (IF:1.255)

28. 韦新兰，张杰，陈丽萍，王卫民，高泽霞，王焕岭＊，团头鲂SPATA4基因的分子克隆及表达分析，海燕策略官网学报，2013, 32, 99-104

29. 吴鑫杰，陈楠，黄春筱，王慧娟，王卫民，王焕岭＊. 低氧对团头鲂心肌细胞凋亡及抗氧化酶活性的影响，海燕策略官网学报，2016,35(3):108-113

 

三、授权专利

王焕岭，张豹，陈伯湘，陈楠，王卫民，刘红. 团头鲂低氧性状相关SNP分子标记及其应用，201510962123.8

王焕岭，陈楠，张豹，王卫民 一种自动化水生动物低氧控制装置，2014.2, CN ZL201320584585

 

四、专著及成果鉴定

王卫民，高泽霞，刘红，王焕岭，黎洁，刘寒，《团头鲂种质资源与育种》，科学出版社，2018

王卫民，高泽霞，刘红，王焕岭，刘寒，蒋恩明，刘冰南，罗伟，曾聪，易少奎. 团头鲂新品种“华海1号”选育与应用，湖北省科技厅成果鉴定，2019

 

五、其他

指导的本科生获得湖北省优秀学士论文3篇；

指导的本科生获得第十二届“挑战杯”全国大学生课外学术科技作品竞赛二等奖1项

指导的研究生湖北省和校级优秀硕士论文共3篇；

 备注 

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